An array of claim 48, which is a microarray. A composition comprising an agonist compound identified by a method of claim 20 and a pharmaceutically acceptable excipient.
Proteins containing these motifs may act alone as monomers, or they may form homo-or heterodimers that interact with DNA.
A method of claim 14, wherein the probe comprises at least 60 contiguous nucleotides. A method for treating a disease or condition associated with decreased expression of functional NAAP, comprising administering to a patient in need of such treatment the composition of claim A method of making a monoclonal antibody with the specificity of the antibody of claim 11, the method comprising: An isolated polynucleotide selected from the group consisting of: A method of detecting a target polynucleotide in a sample, said target polynucleotide having a sequence of a polynucleotide of claim 12, the method comprising: For example, Galcheva-Gargova, Z.
SCAN domain-mediated protein complexes may function to modulate the biological function of transcription factors Schumacher, C. Some of these proteins function as transcription factors that initiate, activate, repress, or terminate gene transcription.
A polyclonal antibody produced by a method of claim An array of claim 48, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 60 contiguous nucleotides of said target polynucleotide.
A method of assessing toxicity of a test compound, the method comprising: These proteins are critical for specifying the anterior-posterior body axis during development and are conserved throughout the animal kingdom. Reviewed in Lewin, B.
A method of screening for a compound that specifically binds to the polypeptide of claim 1, the method comprising: A method of screening a compound for effectiveness as an antagonist of a polypeptide of claim 1, the method comprising: An array of claim 48, wherein said first oligonucleotide or polynucleotide sequence is completely complementary to at least 30 contiguous nucleotides of said target polynucleotide.
Biochemical binding studies have established the SCAN domain as a selective hetero-and homotypic oligomerization domain. A composition of claim 17, wherein the polypeptide is selected from the group consisting of: Transcription factors generally bind to the promoter, enhancer, and upstream regulatory regions of a gene in a sequence-specific manner, although some factors bind regulatory elements within or downstream of a gene coding region.
The C2H2-type zinc finger signature motif contains a 28 amino acid sequence, including 2 conserved Cys and 2 conserved His residues in a CCHH type motif. A method of preparing a polyclonal antibody with the specificity of the antibody of claim 11, the method comprising: Spatial and temporal regulation of gene expression is critical for the control of cell proliferation, cell differentiation, apoptosis, and other processes that contribute to organismal development.
Typically, transcription factors recognize specific DNA sequence motifs of about 20 nucleotides in length. The identity of a cell is determined by its characteristic pattern of gene expression, and different cell types express overlapping but distinctive sets of genes throughout development.
A method for treating a disease or condition associated with overexpression of functional NAAP, comprising administering to a patient in need of such treatment a composition of claim A composition comprising an antagonist compound identified by a method of claim 23 and a pharmaceutically acceptable excipient.
Transcription Factors Transcriptional regulatory proteins are essential for the control of gene expression. The double helix structure and repeated sequences of DNA create topological and chemical features which can be recognized by transcription factors.
A method of generating an expression profile of a sample which contains polynucleotides, the method comprising: An array comprising different nucleotide molecules affixed in distinct physical locations on a solid substrate, wherein at least one of said nucleotide molecules comprises a first oligonucleotide or polynucleotide sequence specifically hybridizable with at least 30 contiguous nucleotides of a target polynucleotide, and wherein said target polynucleotide is a polynucleotide of claim The invention also relates to the assessment of the effects of exogenous compounds on the expression of nucleic acids and nucleic acid-associated proteins.
A method of screening a compound for effectiveness as an agonist of a polypeptide of claim 1, the method comprising:Report of Independent Registered Public Accounting Firm .
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Chapter 6 Forecasting Case Problem 1: Forecasting Food and Beverage Sales 1. Graph of the time series: 2. Analysis of. Find Study Resources. _1_Solution-Case-Chapter 4 pages. 1 Solution Case Chapter 06 Chapter 6 Forecasting Case Problem 2: Forecasting Lost Sales The data used for the forecast is the Carlson sales data for the 48 months preceding the storm.Download